Exercise book on aromatic nitrogen heterocycles chemistry

How to deal with the synthesis and reactivity of five- and six-membered rings

Martine Demeunynck, Sabine Chierici - Collection Current natural sciences

Parution le 09/03/2023

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Résumé

Heterocyclic chemistry is one of the largest branches of chemistry. Heterocycles play major roles in important fields such as medicinal and pharmaceutical chemistries, agrochemicals or polymers. A good understanding of the comparative reactivity of simple five- and six-membered rings, i.e. pyrrole vs pyridine type rings, makes it possible to approach or predict the reactivity of more complex heterocycles. This book is a compilation of exercises, mostly adapted from published works. For more clarity we have chosen to limit ourselves to nitrogen containing heterocycles. The book is mainly aimed to Master students, but it will also be of interest for anyone who wants to train in this important field of synthetic chemistry. The book is organized in five sections. In the first chapter, typical syntheses along with metal catalyzed pathways are presented. The two following chapters are devoted to the chemical reactivity of the six-membered (pyridine, quinoline, azines) and five-membered rings (pyrrole, indole, azoles). In these two chapters, the exercises of increasing difficulties focus on the main types of reactions, including electrophilic and nucleophilic aromatic substitutions, N-alkylation and N-arylation, lithiation and other organometallic reactions, and metal catalyzed cross-coupling reactions. In the fourth chapter, the principles discussed in the previous chapters will be applied to the chemistry of complex polycyclic heterocycles containing both five and six membered rings (pyrrolyl-pyridine, aza-indole, indolizine, purine). The exercise solutions are commented in a separate chapter at the end of the book. Basic notions of nomenclature are given in a short appendix, allowing students to find out a ring structure from its name.

L'auteur - Martine Demeunynck

Martine Demeunynck est directrice de recherches au CNRS, au département de pharmacochimie moléculaire de l'Université de Grenoble Alpes.

L'auteur - Sabine Chierici

Sabine Chierici est enseignant-chercheur au département de chimie moléculaire de l'université Grenoble Alpes.

Caractéristiques techniques

	PAPIER	NUMERIQUE
Éditeur(s)	EDP Sciences
Auteur(s)	Martine Demeunynck, Sabine Chierici
Collection	Current natural sciences
Parution	09/03/2023	09/03/2023
Format	16 x 23.9	-
Couverture	Broché	-
Poids	418g	-
Contenu	-	PDF
EAN13	9782759830817	9782759830824