DNA Microarrays and Gene Expression

From experiments to data analysis and modeling

Pierre Baldi, G. Wesley Hatfield

230 pages, parution le 25/10/2002

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Résumé

Massive data acquisition technologies, such as genome sequencing, high-throughput drug screening, and DNA arrays are in the process of revolutionizing biology and medicine. Using the mRNA of a given cell, at a given time, under a given set of conditions, DNA microarrays can provide a snapshot of the level of expression of all the genes in the cell. Such snapshots can be used to study fundamental biological phenomena such as development or evolution, to determine the function of new genes, to infer the role individual genes or groups of genes may play in diseases, and to monitor the effect of drugs and other compounds on gene expression. This inter-disciplinary introduction to DNA arrays will be essential reading for both biology and computer science researchers wanting to take advantage of this powerful new technology.Contents

A brief history of genomics
DNA array formats
DNA array readout methods
Gene expression profiling experiments: problems, pitfalls and solutions
Statistical analysis of array data: inferring changes
Statistical analysis of array data: dimensionality reduction, clustering, and regulatory regions
The design, analysis, and interpretation of gene expression profiling experiments
Systems biology

Caractéristiques techniques

	PAPIER
Éditeur(s)	Cambridge University Press
Auteur(s)	Pierre Baldi, G. Wesley Hatfield
Parution	25/10/2002
Nb. de pages	230
Format	15,5 x23,5
Couverture	Relié
Poids	515g
Intérieur	Noir et Blanc
EAN13	9780521800228
ISBN13	978-0-521-80022-8