The clinibook

Clinical gene transfer state of the art

Odile Cohen-Haguenauer

400 pages, parution le 16/11/2012

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Résumé

This book provides a 2012 reference for state-of-the-art gene transfer technology and the different aspects of its clinical translation with a focus on European-based initiatives. As examples of successful outcomes, recent clinical trials are presented together with Ethical, Safety and Regulatory issues, which are discussed. The broad range of various technologies is covered whether addressing direct in vivo gene transfer like with AAV, Adeno or non-viral vectors or ex-vivo genetically engineered cells including induced pluripotent stem cells (iPS) with integrating vectors such as retrovirus, lentivirus or transposon-derived systems. The critical path to clinical implementation is covered in the second part describing currently available tools - such as molecular imaging, ex-vivo organ cultures and high-throughput technologies used for evaluation of criteria towards a go-or-no go decision to move to the clinic; in addition, utmost salient biosafety and immunotoxicology aspects are discussed. This book is ideal for postgraduates, undergraduates, scientists, clinicians, regulators and patients' advocacy groups looking for states-of-the-art information as well as emerging prospects - including gene targeting and homologous recombination - in gene transfer intended for clinical translation. Dr Odile Cohen-Haguenauer is the Coordinator of Clingene-NoE, the European Network for the Advancement of Clinical Gene Transfer and Therapy.

Caractéristiques techniques

	PAPIER	NUMERIQUE
Éditeur(s)	EDK
Auteur(s)	Odile Cohen-Haguenauer
Parution	16/11/2012	03/05/2013
Nb. de pages	400	588
Format	17 x 24	-
Couverture	Broché	-
Poids	1136g	-
Contenu	-	PDF
EAN13	9782842541712	9782842542375
ISBN13	978-2-84254-171-2	-