Organic Chemistry
Structure and Function
K. Peter C. Vollhardt, Neil E. Schore
Résumé
ABOUT THE COVER: Hailed as the last line of defense against bacteria, vancomycin is one of the most successful antibiotics used today against drug-resistant bacteria. First discovered by Eli Lilly and Company in 1956, this important natural product possesses a novel and challenging molecular architecture that withstood the attempts of synthetic chemists to construct it in the laboratory for many years. Recently, however, improved synthetic strategies and tactics led to its total synthesis independently by the groups of K. C. Nicolaou at The Scripps Research Institute and the University of California, San Diego (who provided the idea for the cover picture, based on that of Angewandte Chemie International Edition 1999, 38, issue 15), David A. Evans at Harvard University, and Dale L. Boger at The Scripps Research Institute. The front cover shows a molecule of vancomycin (as a ball-and-stick model) hovering over a picture of Streptococcus pyogenes, recent strains of which have shown dangerous drug resistance. The model of vancomycin wraps around to the back, on which we also depict the molecules of erythromycin (top) and penicillin (at right), two of the most celebrated antibiotics of all time. Synthetic strategies used to construct complex molecules, such as these three antibiotics, are discussed in Chapter 8 and subsequently throughout the text. The biological and medicinal context of organic molecules is addressed in many Chemical Highlights, such as Chemical Highlight 20-2, which specifically discusses the antibiotics on the cover, in the general text, and in numerous problems.
L'auteur - K. Peter C. Vollhardt
K. Peter C. Vollhardt - Docteur en chimie de l'University College de Londres, il a mené des recherches en chimie organique au California Institute of Technology, puis à l'Université de Californie, Berkeley. Il a reçu plusieurs prix et est l'auteur de nombreux articles.
L'auteur - Neil E. Schore
Neil E. Schore - Licencié en chimie de l'Université de Pennsylvanie, il est Professeur à l'Université de Californie, Davis. Ses qualités pédagogiques se sont vues récompensées par plusieurs prix.
Sommaire
- Preface: A User's Guide to Organic Chemistry: Structure and Function
- Structure and Bonding in Organic Molecules
- Structure and Reactivity: Acids and Bases, Polar and Nonpolar Molecules
- Reactions of Alkanes: Bond-Dissociation Energies, Radical Halogenation, and Relative Reactivity
- Cyclic Alkanes
- Stereoisomers
- Properties and Reactions of Haloalkanes: Bimolecular Nucleophilic Substitution
- Further Reactions of Haloalkanes: Unimolecular Substitution and Pathways of Elimination
- Hydroxy Functional Group: Alcohols: Properties, Preparation, and Strategy of Synthesis
- Further Reactions of Alcohols and the Chemistry Ethers
- Using Nuclear Magnetic Resonance Spectroscopy to Deduce Structure
- Alkenes and Infrared Spectroscopy
- Reactions of Alkenes
- Alkynes: The Carbon-Carbon Triple Bond
- Delocalized Pi Systems: Investigation by Ultraviolet and Visible Spectroscopy
- Benzene and Aromaticity: Electrophilic Aromatic Substitution
- Electrophilic Attack on Derivatives of Benzene: Substituents Control Regioselectivity
- Aldehydes and Ketones: The Carbonyl Group
- Enols, Enolates, and the Aldol Condensation: α, β-Unssatured Aldehydes and Ketones
- Carboxylic Acids
- Carboxylic Acid Derivatives and Mass Spectrometry
- Amines and Their Derivatives: Functional Groups Containing Nitrogen
- Chemistry of Benzene Substituents: Alkylbenzenes, Phenols and Benzenamines
- Enolates and the Claisen Condensation: Synthesis of β-Dicarbonyl Compounds; Acyl Anion Equivalents
- Carbohydrates: Polyfunctional Compounds in Nature
- Heterocycles: Heteroatoms in Cyclic Organic Compounds
- Amino Acids, Peptides, Proteins, and Nucleic Acids: Nitrogen-Containing Polymers in Nature
- MCAT Questions
- Answers to Exercices
- Photograph Credits
- Index
Caractéristiques techniques
| PAPIER | |
| Éditeur(s) | W.H. Freeman and Company |
| Auteur(s) | K. Peter C. Vollhardt, Neil E. Schore |
| Parution | 23/08/2002 |
| Édition | 4eme édition |
| Nb. de pages | 1210 |
| Format | 21 x 26 |
| Couverture | Relié |
| Poids | 2550g |
| Intérieur | Quadri |
| EAN13 | 9780716743743 |
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